The 49ers are dominating the Titans, as they should, with a 14-3 lead early in the second quarter.

SANTA CLARA — Christian McCaffrey will continue his two-pronged assault on a 49ers’ playoff berth as well as his quest to become the first player in NFL history to have two separate seasons of 1,000 yards rushing and receiving.

The San Francisco 49ers will have their top offensive weapon when they host the Tennessee Titans.

Brock Purdy threw a 4-yard TD to Jauan Jennings that gave the San Francisco 49ers a 7-0 lead over the Tennessee Titans.

The Bay Area broadcast icon is hopeful of resuming his role as radio voice of the 49ers for the last two games of the regular season as he recovers from leukemia that was diagnosed in July, leaving him hospitalized for 23 days and in fear for his life.

QB coach Mick Lombardi, son of UNC’s GM, emerges as a serious candidate to join Bill Belichick’s staff in Chapel Hill.

Preview the Week 15 matchup between the San Francisco 49ers and Tennessee Titans with predictions, odds, over/under, spread, betting lines and more.