Jonathan Taylor’s one-yard touchdown run gave Indianapolis the lead in the fourth quarter, and the Colts withstood a final drive into the red zone by the visiting Arizona Cardinals with less than a minute left to pull out a 31-27 victory on Sunday and improve to 5-1.

It all came to an end on the Indianapolis 9-yard line. On fourth-and-7 with under a minute remaining, Jacoby Brissett fired beyond the reach of Trey McBride, who protested for a penalty flag that never arrived. Cornerback Chris Lammons, the nearest defender, appeared to wrap both arms around McBride at the top of his route.

The Indianapolis Colts just won an incredible game against the Arizona Cardinals in what was a slobber knocker! It was a very concerning game for the Colts secondary which let the Cardinals back ups move the rock up and down the field!

The Indianapolis Colts rally in the fourth quarter to defeat the Arizona Cardinals. Here are the winners and losers from the NFL Week 6 matchup.

Jacoby Brissett, filling in for an injured Kyler Murray, finished 27-for-44 for 320 yards and two touchdowns with one interception.

What channel is Arizona Cardinals vs Indianapolis Colts game on today? How to watch NFL Week 6 football game on TV, streaming Sunday, Oct. 12, 2025.

The Green Bay Packers’ flight to Arizona faced a significant delay on Saturday. That’s one of three reasons why the Packers should be on upset alert on Sunday.

For the first three quarters, the Cardinals have had the second-best defense in the NFL this season. In the fourth quarter, they've had the worst.

With running back Emari Demercado declared out for the Arizona Cardinals ' Sunday game against the Green Bay Packers, D’Ernest Johnson was elevated from the practice squad Saturday as the third back behind Michael Carter and Bam Knight. Johnson was signed to the practice squad on Sept. 29, and Jermar Jefferson came aboard two days later.