There are currently 135 cardinals who are under age 80 and eligible to vote in the conclave, hailing from 71 different countries in the most geographically diverse conclave in history. Already two have formally told the Holy See that they cannot attend for health reasons, bringing the number of men who will enter the Sistine Chapel down to 133.

Two cardinals, Michael Czerny and Chibly Langlois, sat down with ABC News to discuss the challenges facing the church that the new pope will have to face.

Beyond simply picking who the next pope will be, players and gamblers also can guess how many tries it will take the cardinals to choose the leader, which day of the week he’ll be elected, what new name he will decide on, or where his priorities will land on the progressive-conservative scale.