The mechanism of skeletal muscle contraction is a process that relies on calcium signaling. However, the physiological role of calcium-induced calcium release (CICR) through the ryanodine receptor ...
Researchers engineered mice with a mutation (E3896A) in the RyR1 calcium-binding site, eliminating calcium-induced calcium release (CICR) without affecting depolarization-induced calcium release. The ...
The top row of photos show a microscopic view of healthy muscle fibers stained to reveal a variety of irregularities, while the bottom row shows the same but for muscle fibers afflicted by the disease ...