Clemson is favored by 17.5 points against Syracuse, according to the VegasInsider.com consensus betting line. The Tigers have been favored in every game this season, and this is their second-largest point spread of the season (-30.5 points vs. Troy). Worth noting: Clemson is 0-3 against the spread this season.

Clemson football's struggles continued on Saturday as Syracuse walked into Death Valley and handed the Tigers a 34-21 loss.

BOX SCORE CLEMSON, S.C. - Clemson (1-3, 0-2 ACC) racked up a season-high 503 yards of offense, but Syracuse (3-1, 1-0 ACC) ran out to a 24-7 first-half lead en route to a 34-21 Orange win at Memorial Stadium on Saturday.

For the first time, LSU football wins a season opener under Brian Kelly. LSU rallied to knock off Clemson on the road.

The Syracuse Orange (2-1) look to challenge the Clemson Tigers (1-2) today in their first true road game of the year.The Tigers began 2025 ranked No. 4 in the

Clemson football heads back to Memorial Stadium on Saturday for a pivotal Week 4 ACC clash with Syracuse. The Tigers are 1-2 overall and 0-1 in the league after a painful 24-21 loss at Georgia Tech, a result that pushed them out of the national rankings and left little room for error moving forward.

Troy enters with confidence after a 38-20 win over Nicholls State, an FCS program out of the Southland Conference. The Trojans will try to hand Clemson its first loss to a Group of Five opponent since the 2010 Meineke Car Bowl, when South Florida edged the Tigers 31-26 in Charlotte.

Clemson RB Gideon Davidson: Davidson, the No. 3 RB recruit in his class, only played two snaps vs. LSU and had zero carries or targets. In the Troy game, Clemson’s heir apparent at the running back position should get more opportunity.

With 9:00 remaining in the fourth quarter, Klubnik finished a nine-play, 81-yard drive with a nine-yard touchdown pass to Wesco to make the score 34-21. But an interception and a turnover on downs on Clemson’s final two possessions gave Syracuse the victory.