Researchers have discovered that mutations in the FOXJ3 gene act as a "master switch" failure, disrupting how the brain builds its layers and leading to FCD, a primary cause of drug-resistant epilepsy ...

Over the past 15 years scientists have identified hundreds of regions in the human genome associated with heart attack risk. However, efficient ways to explore how these genetic variants are ...

Researchers at Weill Cornell Medicine report that a rare gene mutation that delays Alzheimer’s disease does so by damping inflammatory signaling in brain-resident immune cells in a preclinical study.

In a recent study published by Nature Communications, researchers uncovered a previously unknown method by which androgen-activated androgen receptors (ARs) increase fucosyltransferase 4 (FUT4) ...

Post-traumatic osteoarthritis develops rapidly after joint injury, yet current treatments largely address symptoms rather ...

Biomarkers, molecules found in blood or other biological tissues that signal a condition, disease, or process, are very valuable in helping doctors recommend the most effective treatment for a patient ...

People who carry two copies of the gene mutation most strongly implicated in Alzheimer's disease are almost certain to develop brain changes related to the degenerative disorder, a new study says. A ...

Dental pulp regeneration remains a major clinical challenge. Researchers have discovered that SMAD7 directly forms a transcriptional complex with β-catenin in human dental pulp stem cells, activating ...

Ulcerative colitis (UC) causes misery for millions worldwide. It affects the large intestine, causing pain, cramping, and frequent bowel movements with bloody diarrhea. Although some people go through ...

A genetics‑guided drug, compound 6, targets CARD9 to subtly calm gut inflammation in Crohn’s disease, pointing to safer, longer‑lasting, precision treatments.