When most small-molecule drugs meet a protein target, they nestle close to their intended. But the flirtatious relationship between drug and target is often fleeting, with the drug repeatedly drifting ...

Prior to 2000, many drugs that formed a covalent bond with targets did so non-selectively, which often led to undesired side effects when compared to non-covalent drugs. This led to the belief that ...

Chemical probes that form a covalent bond with a protein target often show enhanced selectivity, potency and utility for biological studies. Despite these advantages, protein-reactive compounds are ...

Researchers compared three different drug delivery models based on ionic liquids. Scientists have developed a powerful API-IL concept to access structural diversity and dual-action pharmaceuticals.

Using an X-ray free-electron laser and time-resolved X-ray solution scattering, researchers have watched, on a femtosecond timescale, the detailed steps that occur when covalent bonds form in solution ...

A research team from Hokkaido University has confirmed a century-old theory by discovering a stable single-electron covalent bond, known as a sigma bond, between two carbon atoms. This unique bond ...

A Hokkaido University research group has successfully demonstrated that carbon-carbon (C-C) covalent bonds expand and contract flexibly in response to light and heat. This unexpected flexibility of ...

Researchers at the US Department of Energy’s Lawrence Berkeley National Laboratory have captured the moment when atoms form a covalent bond. The team happened upon the discovery by accident: they set ...