The MCM helicase is broadly bound across the genome, and its phosphorylation is antagonistically regulated by the kinase DDK and the phosphatase RIF1–PP1. TRESLIN–MTBP recognises the phosphorylated ...
Scientists have uncovered how DnaA, the master key to DNA replication, opens the door to bacterial growth. This breakthroughpaves the way for new antibiotics to combat the rising tide of antibiotic ...
Replication origins in eukaryotic cells initiate a single round of DNA synthesis in each cell cycle. This requires the regulated binding of several conserved initiation proteins, including CDC6/Cdc18p ...
Solution to duplicating the eukaryotic genome 3 billion bps in the human genome. About 50,000 replication origins/genome. Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news ...
Replication origins in Trypanosoma brucei integrate multiple features previously described individually in opisthokonts, revealing a unified structural topology built from strand-specific nucleotide ...
Structural biologists at the University of Wisconsin-Madison today published cryo-electron microscopy structures of the complete bacterial DNA replication restart complex — a molecular machine that le ...
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