Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) has been used as a microbial identification technique for more than a decade, overcoming the limitations of ...

Understanding how proteins interact with each other, and with their ligands, is fundamental to the comprehension of cellular functions and for the efficient application of most biomedical or ...

It's been 20 years since Hillenkamp and Karas developed MALDI. In that time, the soft ionization method, coupled with time-of-flight (TOF) mass spectrometry, has distinguished itself as the enabling ...

Boston-based PerkinElmer Life and Analytical Sciences has released the prOTOF™ 2000, the first commercially available matrix-assisted laser desorption/ionization-time of flight (MALDI-TOF) mass ...

Until recently, clinical diagnostic laboratories predominantly relied on conventional phenotypic ways of diagnosing infections, and sometimes on gene sequencing techniques. The latest advancements in ...

A continuous region of coding sequence can be PCR amplified using a 5′ primer possessing a polymerase binding site and a translation initiation site in-frame with the 5′ end of the test sequence. The ...

The inimitable adaptability of MALDI-TOF/TOF systems enables tissue imaging of intact proteins, as well as of tryptic peptides brought about by on-tissue digestion. Although intact protein imaging can ...

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What is time-of-flight mass spectrometry? How ToF MS has gained more interest since the commercialization of MALDI. Why a high-speed ADC is key to ToF MS performance. Mixed-signal front end that ...

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