Human cells have two copies of each chromosome, and this balance is essential for genes to be expressed in the appropriate ...

Mitochondria are central regulators of cellular metabolism, redox balance, and cell survival in the nervous system. In recent years, growing evidence has ...

SARM1 is known to trigger axon degeneration—the process by which the signal-sending part of a nerve cell breaks down. In ADOA, it's the activation of this process that leads to damage in the retinal ...

This mitochondrial process supports the brain cells essential to learning, memory and social recognition. We know that mitochondria are the powerhouses of the cell, but what role do they play in ...

Multiple sclerosis (MS) affects an estimated 2.3 million people worldwide. Approximately 80% of people with MS have inflammation in the cerebellum, the part of the brain that helps control movement ...

Apoptosis-Inducing Factor (AIF) is a multifunctional mitochondrial protein that plays a crucial role in both cell death and mitochondrial bioenergetics. Beyond its pro-apoptotic function, AIF is ...

Some brain disorders are straightforward, such as the direct frontal lobe assault of a concussion or traumatic brain injury. Others, like Alexander disease, are akin to guerilla warfare. Patients ...

(A) In early/mid-stage PD, the nigrostriatal pathway (indicated by red arrow) is primarily affected, leading to impaired voluntary movement control due to dopamine depletion in the striatum. During ...

An international team led by researchers from the University Medical Center Göttingen (UMG), Germany, has used advanced ...

Chronic disease research increasingly points to the centrality of metabolic remodeling and mitochondrial dysfunction in dictating disease onset, severity, ...

Despite being renowned as the “powerhouse of the cell,” mitochondria can also be a source of heartache for those living with mitochondrial disease—especially when planning to have children. Because ...