It is known that there are close relationships between bone destruction and tumor growth in bone metastasis. RANKL is a central factor in bone metastasis, inducing osteoclastogenesis mediated by its ...

New research by Hiroshi Suzuki and colleagues shows that reverse signalling of receptor activator of nuclear factor-κB (RANK; also known as TNFRSF11A) ligand (RANKL; also known as TNFSF11) in ...

Infertile men have few treatment options. Here, we demonstrate that the transmembrane receptor activator of NF-kB ligand (RANKL) signaling system is active in mouse and human testis. RANKL is highly ...

During orthodontic tooth movement, osteoclastic bone resorption is essential for alveolar bone remodeling. It is well known that the differentiation of osteoclasts is regulated by RANKL. However, the ...

A potential new therapeutic option for the treatment of nonmuscle invasive bladder cancer: Combination of intravesical oncotherad immunotherapy and platelet rich plasma (PRP). This is an ASCO Meeting ...

The tumor necrosis factor (TNF) superfamily represents a large, loosely related, and versatile group of homotrimeric cytokines. There has been considerable interest in the structure of these proteins, ...

Scientists at Princess Margaret Cancer Centre have discovered that blocking the master regulator of bone renewal stops osteosarcoma - the most common primary bone cancer in children and teens, and the ...

Future Oncol. 2013;9(11):1609-1622. The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the ...

Researchers have revealed that RANKL expressed by osteocytes is essential for the bone remodeling during orthodontic tooth movement. This result can facilitate the development of novel therapeutic ...

Tokyo Medical and Dental University(TMDU) research team demonstrated that osteocytes have a crucial role in orthodontic tooth movement as the major source of receptor activator of nuclear factor-κB ...