DNA replication proceeds through specialised structures known as replication forks, where parental duplex DNA is unwound and copied. The faithful progression and stability of these forks are essential ...

University of Iowa-led study has revealed the unexpected structure adopted by the DNA repair protein RAD52 as it binds and protects replicating DNA in dividing cells. A University of Iowa-led study ...

Researchers at The University of Texas MD Anderson Cancer Center have developed a new imaging method, known as RF-SIRF, that quantitatively detects and maps reversed DNA replication forks with ...

In turn, this slowed new DNA synthesis at replication forks, structures in which double strands of DNA separate to begin the copying process. The cells' attempt to restart the stalled replication fork ...

A University of Iowa-led study has revealed the unexpected structure adopted by the DNA repair protein RAD52 as it binds and protects replicating DNA in dividing cells. This new structural and ...

A cancer drug target already being investigated in clinical trials turns out to be doing something even more consequential than researchers realized. Scientists at Scripps Research have discovered ...

Despite the importance of DNA replication, numerous aspects of this process are still poorly understood. One fundamental question is: how do replication forks efficiently progress through chromatin?

Structural biologists at the University of Wisconsin-Madison today published cryo-electron microscopy structures of the complete bacterial DNA replication restart complex — a molecular machine that le ...

A University of Iowa-led study has revealed the unexpected structure adopted by the DNA repair protein RAD52 as it binds and protects replicating DNA in dividing cells. This new structural and ...