Advanced Tools to Investigate All Compound Classes of GPCR Activation Among targets of interest for the pharmaceutical industry, GPCRs account for more than 30% of all drug screenings. The complexity ...

During neural development, graded distribution of extracellular cues in the microenvironment causes asymmetric generation of second messengers across the growth cone in order to guide the axon along ...

Scientist have created photosensitive mimics of a class of signaling molecules, thus enabling their actions to be regulated by light, and affording new insights into the communications networks that ...

A new study describes the development of a cAMP analogue that specifically activates only Epac2, one of several cAMP-responsive proteins. Furthermore, the analogue activates Epac2 more potently than ...