At the recent American Society of Hematology annual meeting, researchers presented preclinical data examining how transdifferentiation between hematopoietic lineages -- driven by LMO2 expression and ...

Cellular reprogramming is like the fairytale of spinning straw into gold: you take an abundant, mundane cell type, dose it with a cocktail of chemicals, and voilà—now you have an unlimited supply of ...

How can a specialized cell change its identity? A research team investigated a 100% effective natural example of this phenomenon, which is called transdifferentiation. This process, by which some ...

We report on the case of a 41-year-old man with a 2.1-cm primary malignant melanoma of the skin, located on the crown of the head. The tumor was stage pT4 (with invasion of contiguous structures), ...

Tsukuba, Japan—Vascular diseases such as atherosclerosis, pulmonary hypertension, and cardiac fibrosis are associated with a reorganization of the structure of blood vessels. Researchers led by the ...

This news release is available in Spanish. All it takes is one molecule to reprogram an antibody-producing B cell into a scavenging macrophage. This transformation is possible, new evidence shows, ...

Researchers have discovered that a leukemic cell is capable of transforming into a non-cancerous cell through epigenetic changes. All the tissues of our body have the same DNA, but they perform very ...

Conrad Waddington famously visualized development as a landscape in which a young cell differentiates much as gravity acts on a ball, leading it down forked canals that represent alternate lineages. A ...

Metaplasia is defined as the replacement of a fully differentiated cell type by another. There are several classical examples of metaplasia, one of the most frequent is called Barrett's esophagus.

Direct reprogramming or Transdifferentiation is a way of inducing changes in the cell type from one lineage into another lineage, bypassing pluripotency. This approach is an innovative choice to ...