Progression of focal segmental glomerulosclerosis (FSGS) is associated with podocyte loss and hypertrophy of remaining podocytes; however, the mechanisms underlying these processes are unknown. New ...

The phosphoinositide 3-kinase–AKT–mechanistic target of rapamycin (PI3K–AKT–mTOR) pathway is one of the most commonly activated pathways in human cancer, and a number of agents have been developed ...

An interview with David M. Sabatini, M.D., Ph.D., conducted by April Cashin-Garbutt, MA (Cantab). Can you please give a brief introduction to the mechanistic target of rapamycin (mTOR) cellular ...

Sepsis, one of the most acute and serious disease complications in the intensive care unit, is caused by various infections and results in life-threatening organ dysfunction. The intestinal barrier ...

As the cell's molecular control center, the mTor kinase regulates cellular metabolism, growth and division. However, in cells affected by pathological change, the regulation goes awry. Scientists have ...

Impact of obesity and adiponectin signaling in patients with renal cell carcinoma: A potential mechanism for the obesity paradox.

Renal cell carcinoma (RCC) develops resistance to most of the conventional therapies. In recent years inhibitors are being used to interfere with growth of cancer cells at molecular level and are ...

New York, Aug. 24, 2023 (GLOBE NEWSWIRE) -- Reportlinker.com announces the release of the report "mTOR Inhibitors Global Market Report 2023" - https://www ...

A phase I study to assess the safety, tolerability, and PK of dovitinib (D) in combination with gemcitabine (G) and capecitabine (C) in patients with advanced solid tumors. Phase I trial of daily ...

Breckenridge Pharmaceutical, Inc., the U.S. subsidiary of Towa International that markets, distributes, and sells generic pharmaceuticals in the United States, announced today the launch of Everolimus ...

Actinic keratosis affects more than 10% of Europeans and is considered the most common pre-cancerous dermatological condition driven by an overactive PI3K/mTOR pathway. Bimiralisib gel is a selective ...