Proteomics experiments on Drosophila reveal sex-specific effects in aging, and an important role for a protein called DIP-β.

This important study builds on previous work from the same authors to present a conceptually distinct workflow for cryo-EM reconstruction that uses 2D template matching to enable high-resolution ...

The ReproSci project retrospectively analyzed the reproducibility of 1006 claims from 400 papers published between 1959 and 2011 in the field of Drosophila immunity. This project attempts to provide a ...

GMCL1-dependent degradation of 53BP1 suppresses mitotic surveillance, tuning p53 activation thresholds that govern cell fate decisions and cellular responses after mitosis.

Trained immunity provides a unifying framework linking innate immune memory to both protective and maladaptive inflammation ...

Distinct patterns of SARS-CoV-2 viral dynamics in saliva reveal heterogeneity that cannot be sufficiently explained by conventional clinical characteristics or microRNA profiles alone.

CDK2-mediated TBK1 degradation via Dtx4 represents a previously unrecognized regulatory mechanism that modulates antiviral immunity in fish.

A context-driven memory model simulates a wide range of characteristics of waking and sleeping hippocampal replay, providing a new account of how and why replay occurs.

BK and CaV1.3 channels interact early during biogenesis, assembling intracellularly before membrane localization, indicating coordinated processes for functional coupling.

In silico antibody accessibility analysis indicates that ectodomain epitopes are transiently exposed, while MPER epitopes are virtually always occluded in the pre-fusion trimer.

A large-scale investigation of carnivoran brain diversity, providing a unified description of folding patterns, their relationship to behaviour and ecology, and the foundation for future ...

Machine learning models reveal that histone marks are predictive of gene expression across human cell types and highlight important nuances between natural control and the effects of CRISPR-Cas9-based ...