Thorax

Establishing the top 10 research priorities for lung volume reduction treatment for people with COPD

Lung volume reduction procedures are an established evidence-based aspect of chronic obstructive pulmonary disease (COPD) ...
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Periodic breathing at altitude is an adaptive response: lessons for similar conditions at sea level

Healthy adult lowlanders sojourning above altitudes of 3000 m naturally develop periodic breathing (PB) ~40% of total sleep ...
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Survival in congenital central hypoventilation syndrome (CCHS): data from the European CCHS Consortium

Introduction Congenital central hypoventilation syndrome (CCHS) is a rare disorder characterised by autonomic dysfunction and impaired respiratory control. While advances in ventilatory support have ...
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Nasal high flow oxygen therapy in patients with COPD reduces respiratory rate and tissue carbon dioxide while increasing tidal and end-expiratory lung volumes: a randomised ...

Correspondence to Amanda Corley, Critical Care Research Group, Level 5 CSB, The Prince Charles Hospital, Rode Rd, Chermside, Brisbane, QLD 4032, Australia; amanda.corley{at}health.qld.gov.au The ...
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Hypoxia and tissue destruction in pulmonary TB

Background It is unknown whether lesions in human TB are hypoxic or whether this influences disease pathology. Human TB is characterised by extensive lung destruction driven by host matrix ...
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Diving and the risk of barotrauma

Department of Internal Medicine, University Hospital Zurich, Switzerland. STUDY OBJECTIVES: Pulmonary barotrauma (PBT) of ascent is a feared complication in compressed air diving. Although certain ...
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Non-invasive ventilation in acute respiratory failure

S Baudouin, S Blumenthal, B Cooper, C Davidson, A Davison, M Elliot, W Kinnear (Chairman), R Paton, E Sawicka, L Turner (Secretary) Non-invasive ventilation (NIV) refers to the provision of ...
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Acidosis, non-invasive ventilation and mortality in hospitalised COPD exacerbations

Background Reports of non-invasive ventilation (NIV) use in clinical practice reveal higher mortality rates than in corresponding randomised clinical trials. Aim To explore factors related to chronic ...
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Pulmonary alveolar proteinosis: clinical aspects and current concepts on pathogenesis

aRoyal Brompton Hospital and Imperial College School of Medicine at the National Heart & Lung Institute, London SW3 6NP, UK, bMRC Immunochemistry Unit, Department of Biochemistry, University of Oxford ...
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Radiomics analysis to predict pulmonary nodule malignancy using machine learning approaches

Background Low-dose CT screening can reduce lung cancer-related mortality. However, most screen-detected pulmonary abnormalities do not develop into cancer and it often remains challenging to identify ...
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Incidence and recognition of acute respiratory distress syndrome in a UK intensive care unit

Correspondence to Dr Charlotte Summers, Division of Anaesthesia, Department of Medicine, Box 93, Level 4, Addenbrooke's Hospital, CUHNHSFT, Hills Road, Cambridge CB2 OQQ, UK; ...
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The overlap syndrome of asthma and COPD: what are its features and how important is it?

1 Centre for Asthma and Respiratory Diseases, University of Newcastle, Newcastle, Australia 2 Department of Respiratory and Sleep Medicine, John Hunter Hospital, Newcastle, Australia Professor P ...