imageimageIn spermatogenesis, loss of promoter DNA methylation reactivates retrotransposons in patterns shaped by chromatin modifications and the binding of DNA methylation-sensitive transcription ...

Therefore, the aim of this study was to perform an extensive multi-omic analyses on cryopreserved pre-mortem human left ventricular myocardium to uncover the influence of DM in end-stage HF and to ...

Lymphedema is a chronic lymphatic disorder characterized by persistent tissue swelling, pain, and recurrent infections, often secondary to cancer treatment, surgery, or obesity. Obesity-associated ...

imageimageThe ALS-associated VAPB P56S mutation disrupts ER–mitochondria associated membranes (ER-MAMs) and leads to mitochondrial stress and activation of the integrated stress response (ISR). ISR ...

Glioblastoma Multiforme (GBM) is a highly malignant brain cancer with limited effective therapies. Neurodevelopmental pathways have been implicated in glioma formation, with key neurodevelopmental ...

Generating longitudinal and multi-layered big biological data is crucial for effectively implementing artificial intelligence (AI) and systems biology approaches in characterising whole-body ...

imageimageTight control of separase activity is essential for prolonged meiotic arrest of mammalian oocytes. Here, removal of securin and cyclin B1-Cdk1 dual inhibition of separase in mouse oocytes ...

imageimageIgA proteases are produced by some gut bacteria and interfere with the ability of the immune system to target bacteria. This study characterizes the recognition mechanisms of two M64 ...

Lysophosphatidylinositol (LPI) bioactive lipids are implicated in energy homeostasis and metabolic disorders, but their roles in insulin signaling remain unclear. This study reveals hepatic ...

Silencing evolutionary young retrotransposons by cytosine DNA methylation is essential for spermatogenesis, as failure to methylate their promoters leads to reactivation, meiotic failure, and ...