The Detroit Lions will play the San Francisco 49ers at Levi’s Stadium on Sunday, Dec. 29. Kickoff is at 8:15 p.m. ET on ABC.

The Lions (13-2) are looking to continue their winning ways against the 49ers (6-9) and keep their spot at the top of the NFC ...

The Niners face the team they took out in the NFC Championship in a role reversal with the Lions looking like a Super Bowl ...

The Lions have already defeated the Vikings once this season at U.S. Bank Stadium. If Detroit wins again, they're in based on ...

The Lions and 49ers kick off tonight at 5:15 p.m. PT (8:15 p.m. ET) on ABC, ESPN and ESPN Plus. Looking for the ManningCast?

Back in Week 4 at Lambeau Field, the Minnesota Vikings held a 28-0 lead over the Green Bay Packers but had to survive a ...

According to NFL Pickwatch, 93 percent of NFL analysts are picking the Lions to defeat the 49ers at Levi's Stadium. One of the key players on the 49ers' offense that Detroit's defense must limit is ...

During a wild Week 17, the Colts choked away any chance at a playoff berth by losing to the Giants. Heading into the final ...

The NFC’s No. 1 seed will come down to the final game of the regular season when the Detroit Lions host the Minnesota Vikings ...

Who will make the NFL playoffs? The Tampa Bay Buccaneers, Atlanta Falcons, Denver Broncos, Miami Dolphins, Cincinnati Bengals ...

SAN FRANCISCO (WNEM) - The Detroit Lions are in San Francisco to take on the 49ers for Monday Night Football. Kickoff is set for 8:15 p.m. The Lions are still fighting for the No. 1 seed in the NFC, ...

On Monday, Reader will take the field with the Lions as they venture back to the site where they suffered a similar feeling ...