Anti-obesity drugs such as semaglutide (Ozempic, Wegovy) are also promising for the treatment of alcohol use disorder and ...

A team of pharmaceutical researchers is reporting a newly recognized process of drug metabolism in the intestines - followed by recycling through the liver - that could have important implications for ...

The human liver plays a pivotal role in drug metabolism, largely attributable to the diverse family of UDP-glucuronosyltransferases (UGTs) that catalyse glucuronidation reactions. This conjugation ...

The liver is accountable for metabolizing most medications and is therefore one of the primary tissues affected by adverse drug reactions. Most classes of medicine can cause drug-induced liver injury ...

The liver plays a critical role in the metabolism and clearance of more than 70% of marketed drugs. Furthermore, toxicity to the liver is a major reason for preclinical and clinical drug failures.

High doses of cinnamon, especially in supplements or oils, may interfere with how the body metabolizes medications by activating or inhibiting liver enzymes. These interactions could make medications ...

The liver's complex role in metabolising drugs makes it both a critical consideration and potential stumbling block ...

The liver is the principal site of the body's drug metabolism, so it isn't surprising that drug-induced liver injury (DILI) can occur. However, despite the common use of medications in today's society ...

Metformin has been prescribed to people with type 2 diabetes to manage blood sugar for more than 60 years, but scientists ...

A MedUni Vienna study has identified a new approach to the drug treatment of metabolic liver diseases. In an experimental study, pharmacological inhibition of an enzyme that plays a central role in ...

Researchers identified microRNA-93 as a genetic driver of fatty liver disease and showed that vitamin B3 can effectively ...

Obesity affects the way drugs behave in the body. Yet, our regulatory systems ignore this fact entirely. At a recent virtual workshop on drug safety and efficacy in people with obesity, Food and Drug ...