The growth rate of the atmospheric abundance of methane (CH 4) reached a record high of 15.4 ppb yr −1 between 2020 and 2022, but the mechanisms driving the accelerated CH 4 growth have so far been ...

We demonstrate that substitutionally inert octahedral metal complexes, such as the iridium (III) carbene complex (1a), provide a useful source of potent inhibitors for unexplored oncogenic protein ...

Rapid pathogen detection is crucial for effective disease management, particularly in bloodstream infections. Current molecular diagnostics often require nucleic acid preamplification, adding time and ...

Heritable microbes can regulate insect reproduction in diverse ways (1). For example, some symbionts which have been called reproductive manipulators, cause cytoplasmic incompatibility, male-killing, ...

This study was supported in part by Grants-in-Aid for Research on Innovative Areas from the Ministry of Education, Culture, Sports, Science and Technology, Japan (KAKENHI Grant No. JP16H06452 to T.D.) ...

Using novel mouse models, we establish cyclin-dependent kinase 12 (CDK12) as a bona fide tumor suppressor gene in tubo-ovarian high-grade serous carcinoma, demonstrating that its loss drives increased ...

Nav1.8 voltage-gated sodium channels are strongly expressed in human primary pain-sensing neurons (nociceptors) and a selective Nav1.8 inhibitor VX-548 (suzetrigine) has shown efficacy for treating ...

In This IssueThe chemical by-products of dimethyl sulfide (DMS), a source of atmospheric sulfur emissions from the ocean, contribute to aerosol formation, influencing cloud formation, albedo, and ...

Turbulence at centimeter scales plays a pivotal role in shaping the overturning circulation of the deep ocean (1, 2), as well as the ocean’s capacity to distribute and store climate-critical tracers ...

The fishery for Antarctic krill (Euphausia superba, hereafter referred to as “krill”) is one of the world’s largest fisheries for crustaceans (1), and by far, the largest fishery in the Southern Ocean ...

Long-term light at night (LAN) exposure poses a health threat to nocturnal lab animals. Whether diurnal animals suffer the same deleterious effect imposed by LAN and how it works are still open ...

A cure for chronic hepatitis B requires eliminating or permanently silencing covalently closed circular DNA (cccDNA). A pivotal target of this approach is the hepatitis B virus (HBV) X protein (HBx), ...